Sex differences in the application of noninvasive auditory and visual neurostimulation to alter neuropathology in mouse models of Alzheimer's disease
@ Atlanta VA Medical Center
As a research scientist, I investigate how non-invasive audio-visual neurostimulation at specific frequencies (aka flicker) alters microglia's engulfment of amyloid plaques, and microglia morphology in a mouse model of Alzheimer's disease.
Immunohistochemistry of microglia (green) in 5XFAD mouse models of Alzheimer's disease hippocampus to study neuropathology post audiovisual flicker
40x confocal microscopy of a mouse hippocampus area CA1, pyramidal layer
^ 3D mouse brain hippocampus area CA1, pyramidal layer
green = microglia; red=amyloid beta plaques, yellow = colocalized microglia and amyloid plaques
Reconstruction of microglia in Imaris software to examine changes in morphology and engagement with toxic amyloid beta plaques