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As a research scientist, I investigate how non-invasive audio-visual neurostimulation at specific frequencies (aka flicker) alters microglia's engulfment of amyloid plaques, and microglia morphology in a mouse model of Alzheimer's disease.
Immunohistochemistry of female 5XFAD mouse hippocampus to study neuropathology post audiovisual flicker
Immunohistochemistry of female 5XFAD mouse hippocampus to study neuropathology post audiovisual flicker
20x confocal microscopy of a mouse hippocampus area CA1, pyramidal layer
20x confocal microscopy of a mouse hippocampus area CA1, pyramidal layer
green = microglia; red=amyloid beta plaques, yellow = colocalized microglia and amyloid plaques
green = microglia; red=amyloid beta plaques, yellow = colocalized microglia and amyloid plaques
^ 3D mouse hippocampus area CA1, pyramidal layer
^ 3D mouse hippocampus area CA1, pyramidal layer
>> Reconstruction of microglia in Imaris software to examine changes in morphology
>> Reconstruction of microglia in Imaris software to examine changes in morphology
Undergraduate student researcher Christopher He
Georgia Tech President's Undergraduate Research Award Recipient 2021
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