Sex differences in the treatment of neuropathology in mouse models of Alzheimer's disease
@ Atlanta VA Medical Center
As a research scientist, I investigate how non-invasive audio-visual neurostimulation at specific frequencies (aka flicker) alters microglia's engulfment of amyloid plaques, and microglia morphology in a mouse model of Alzheimer's disease.
Immunohistochemistry of female 5XFAD mouse hippocampus to study neuropathology
Immunohistochemistry of female 5XFAD mouse hippocampus to study neuropathology
^ 20x confocal microscopy of a mouse hippocampus area CA1, pyramidal layer
^ 20x confocal microscopy of a mouse hippocampus area CA1, pyramidal layer
green = microglia; red=amyloid beta plaques, yellow = colocalized microglia and amyloid plaques
green = microglia; red=amyloid beta plaques, yellow = colocalized microglia and amyloid plaques
^ 3D mouse hippocampus area CA1, pyramidal layer
^ 3D mouse hippocampus area CA1, pyramidal layer
>> Reconstruction of microglia in Imaris software to examine changes in morphology
>> Reconstruction of microglia in Imaris software to examine changes in morphology
Undergraduate student researcher Christopher He
Georgia Tech President's Undergraduate Research Award Recipient 2021
3D printed and customized mouse chambers controlled by Arduinos to condition audiovisual gamma flicker with reward (Design - undergraduate student researcher, PURA recipient Christopher He). Chris's low-cost design facilitates open science and collaboration as this design is available for free online, is easily modifiable, and cost $60 to build.